Can you trash a card that you have already played, when remodelling? E.g. I play a village, then a Worksop, then Remodel - trashing the Workshop I just played? It says from your hand, but am unclear if there is a distinction between hand and play.
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No, you cannot do this. Your "hand" always refers to cards that you physically keep in your hand. Cards that you have played this turn are in a different place, the "in-play" area.
On page 6 of the rulebook:
Pages 9 and 10 also show picture examples of the different places cards might be; including hand, deck, discard, or in-play.