Given that Misthollow Griffin can be cast from exile, if you somehow use Mimic Vat to imprint the Misthollow Griffin and then cast Misthollow Griffin and remove it from exile, can you still make Misthollow Griffin tokens via Mimic Vat?
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No. The exiled card has ceased to be in exile, so the activated ability will be unable to find it when it resolves. Misthollow Griffin isn't even required for this question, sinceMimic Vat itself is constantly exiling creatures, and then returning those cards to their owners graveyard. You can no longer make copies of cards that were returned to their owners graveyards, neither can you copy Misthollow Griffin if it changes zones.
Mimic Vat contains linked abilities. The first triggered ability exiles cards when they die (technically, these do not have to be creature cards, they only need to be creatures when they die). The second activated ability returns a token copy of the card to the battlefield until the beginning of the next end step. There are some unusual corner cases where it is important to know which ability was responsible for exiling a particular card, if some card gains multiple exile abilities, since only the abilities that are linked are able to refer to the cards exiled in that way. (Note: The CR give an interesting example with Quicksilver Elemental, Arc-Slogger, and Sisters of Stone Death that I won't review here)
So, what happens if the card is no longer in exile (or is exiled again by some other effect)? It becomes a new object, with no relation to it's precious existence. What this means is that Mimic Vat cannot find the card that was exiled, and therefore cannot copy it.
No you cannot.
As with any imprint cards, the ability related to the imprinted card is only available as long as the imprinted card does not change zone, otherwise the game loses track of the relationship between Mimic Vat and the imprinted card.
For instance, a Chrome Mox would not produce mana if the imprinted card leaves the exile zone.
If the Misthollow Griffin leaves the exile zone, you cease to be able to make "a copy of the exiled card", as it no longer counts as "the exiled card".
It's not actually the fact of having been exiled at some point that makes a card an "exiled card", it's the fact of being in the exile zone.
I'd make an analogy of this with, let's say, an Aura that "enchants a green creature". If the creature later ceases to be green, the enchantment ceases to be valid. Likewise, with Mimic Vat, if the exiled card ceases to be exiled, it has broken the terms of the agreement (as it were) and is no longer copiable by the Vat.