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If you are acting as a guardian, you can simplify a bit the part about the monsters movement as you will do it and focus more on the parts of the turn their players can actually do an action. Giving them a quick reference card before you explain the things can help them follow better your explanation. Also with many new people I'd maybe do a pre prepared ...

In terms of rule tweaks (as opposed to expansions), Richard Launius' house rules (pdf) are as close to canonical as it gets (he designed the game). They're linked in the accepted answer, but there's a lot more, so I think it's worth having a summary here. The document is organized by rule type; to help make it easier to find rules to tweak the difficulty how ...

To make the game slightly easier, deal either the double of cards or one extra than the investigator needs and pick the one(s) that the most thematically appropriate to the character and discard the rest. This makes trading items in the first few turns almost redundant thus allowing to focus on monsters and/or gates.

It's worth adding that there are two versions of Curse of the Dark Pharaoh. The original release was an excellent addition, as it added the highly thematic exhibit card class. However it suffers from dilution in an all-in game, as the chances to draw encounter which refer to the Exhibit items severely diminish. The revised version of Curse of the Dark ...