The general answer to this question is no.
Go players play for win or loose, not for the difference of score. When a player lying behind does not see a chance to turn the outcome of the game into Eir favour, E resigns.
The caveat here is the word general:
There are some tournament formats (used, e.g., in the Go-to-innovation tournament in Berlin, Germany) using a scoring system based on point differences. The Hahn system assign a full point only with a score difference of 40 points or more, each 10 points missing on board make the score 0.1 smaller.
Also, in the Korean gambling Go bangnekibangneki score differences (in terms of 10 points on the board) were used to measure the amount of money won or lost.