In various flavors of Fluxx, there are Creepers; they all say "You cannot win if you have this card in front of you, unless a card says otherwise." In Cthulhu Fluxx, there are frequently Goals that have creepers on them.
If there's a Goal out there that has a Creeper and a Keeper on it, and I have the right Keeper, the right Creeper, and one other Creeper, can I win?