After my barrel fails, can I use a missed card from my hand to fend off a Bang! card?
Or does it mean that I will immediately take a hit?
You can still use a Missed card like normal if the barrel fails. From the rules:
Example. C is the target of A's BANG! C has a Barrel card in play: this card lets him “draw!” to cancel a BANG! card. So, C flips the top card of the deck and puts it on the discard pile: it's a 4 of Hearts. The use of the Barrel is successful and cancels the BANG! If the flipped card were of a different suit, then the Barrel would have had no effect, but C could have still tried to cancel the BANG! with a Missed! card.
answered Sep 13 '14 at 23:25
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This also applies to Jourdonnais's ability which means he can use his ability, the barrels ability and finally play a miss if needed.– Joe WSep 14 '14 at 11:17