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I tried Googling the answer, but it seems like different sources say different things, and I can't find anything about it in the Commander rules (on the official Commander website). My main takeaway is that it's arbitrary based on your playgroup, but it seems like a rather unsatisfying answer.
Does anyone know definitively how many poison counters it takes to kill someone in EDH?
It is 10 just like in a normal game. The only format that changes the number of poison counters needed to cause a player to lose a game is Two-Headed Giant.
704.5c If a player has ten or more poison counters, he or she loses the game. Ignore this rule in Two-Headed Giant games; see rule 704.5u instead.
704.5u In a Two-Headed Giant game, if a team has fifteen or more poison counters, that team loses the game. See rule 810, “Two-Headed Giant Variant.”
