Can the cards be shuffled and used as an expansion pack? Or are there other differences which prevent this?
(PS: Are they equally fun? Or should I just refrain from buying Crabs Adjust Humidity?)
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Seeing as it's billed as an "unofficial expansion to Cards Against Humanity" (see website), I think the answer must be "yes". That said, it does appear the card backs are different, so you may need to slap everything into opaque-back sleeves to make it work really well.
I have both Crabs against Humidity and Guards against Insanity. They can be mixed with Cards against Humanity. They have different backs but that is not a real problem.
Personally, I think the original (and the original expansions 1 to 6) are better. I use the following arguments: