Most of what I've read about Ticket to Ride focuses on "constructive" strategies of getting long destination routes and building them out for their large bonuses, including the longest route bonus. This allows one or more players to get over 200 points, but presumes a minimum of "blocking" from one player to another.
On the other hand, if players are inclined to block each other, then long destination routes might be a liability (because they can't be completed, and earn a negative bonus). In such a game, it seems like the trick is to take the two shortest destinations, build them "fast," and then spend the rest of the game blocking other people's routes. In such a game, scores might be closer to 100 than 200.
If only one player is playing "blocking," this strategy might not work, but it seems that if four or five (out of five) are playing this way, the game would play very differently than as discussed in the first paragraph. Just how would it play differently? Have I gotten at least some of the changes right in the previous paragraph>