For each creature target player controls, create a token that's a copy of that creature.
Destroy target artifact or enchantment. You gain 2 life.
Will this effect an enchantment on a creature which has hexproof?
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From the Comprehensive Rules:
702.11b “Hexproof” on a permanent means “This permanent can’t be the target of spells or abilities your opponents control.”
Appetite for the Unnatural targets the enchantment, not the creature itself, so it will resolve and destroy the enchantment (unless the enchantment itself somehow has hexproof too).
Clone Legion targets a player, not creatures, so unless that player has hexproof, it will make a copy of all their creatures, including the ones with hexproof. Any enchantments on those creatures won't be copied.