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I have just started playing the game and realized that it would be a very different game depending on which virus gets the sticker in the first game. I am wondering if my think is correct and which color would be the easiest verse the hardest?

February spoilers:

I am talking about the virus which becomes incurable in February of the game

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  • We won the first 4 games in a row, struggling in the first 2, getting sort of easy wins on#3 and #4, and then got decimated in#5. So luck plays a role and how well you predict the best combination of roles for the game.
    – Gnudiff
    Feb 8, 2020 at 12:51
  • We ended up with a board that wasn't fun the play in December since with the setup we had we had a very low chance of winning because of the objectives and decided not to play the last round. We enjoyed the experience but the game definitely kicked our ass.
    – Styxsksu
    Dec 18, 2020 at 17:13

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There is some difference in difficulty based on which color becomes faded; but shouldn't change things very much compared to other random chance elements in the game.

As a whole, Blue being faded makes for the most difficult games.

The biggest difference between the colors is that they each have a different number of connections to other colors. This increases the number of faded counters that will end up on other colors on average.

Based on this statistic, blue is a difficult color to get, because it has 13 total connections to other colors, compared to 9 for Black, 8 for Yellow, and 6 for Red.

There are some other factors such as the number of internal connections; but ultimately which random cards you draw and when both from the player card deck and the infection deck will have a bigger luck-based impact on how difficult it is compared to which of the 4 colors ends up faded.

For more details and analysis, see here (where I got my numbers from).

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