Instances of Annihilator are independent of each other. Each instance triggers separately.
702.86a Annihilator is a triggered ability. “Annihilator N” means “Whenever this creature attacks, defending player sacrifices N permanents.”
702.86b If a creature has multiple instances of annihilator, each triggers separately.
Note that multiple instances don't simply add up. They trigger and resolve separately. That usually doesn't matter, but it does give players an opportunity to cast spells and activate abilities between those instances, if desired. Also there are ways to counter triggered abilities, so one of these counters would not be enough to counter multiple instances of Annihilator on the stack.