I am mostly retired from the Yu-Gi-Oh TCG, but sometimes check what's going on in the game and play around a bit in a deck garage. I had a deck that brought out Isolde Two Tales of the Noble Knights, searched Doppelwarrior to the hand, went into Crystron Halqifibrax, and did Accel Synchro Summoning during my opponent's turn, trying to make multiple hand disruption plays like PSY-Framelord Omega, Trishula Dragon of the Ice Barrier, or Desert Locusts. I know other, more popular decks such as Infranoble also made Link climbing plays using Isolde into Halqifibrax.
What good lines of play are available for Isolde now that Halqifibrax is in hibernation? Let's consider two cases.
In the first case, suppose you've just Special Summoned Isolde from the Extra Deck with no other monsters on your field. You can search anything in the game for each of its effects.
In the second case, suppose you have one monster already on your field that can be used as further material, in addition to the materials used to Special Summon Isolde. It's nothing remarkable on its own, just some arbitrary monster. For the sake of concreteness to prevent answers from branching out in a bunch of directions, we'll say it's Nimble Momonga.
If the question is still too broad, narrow it to "what is the best line of play in these cases which leads to hand disruption plays for an attrition strategy?"