There are two instances in the Magic: The Gathering comprehensive rules that say that a replacement effect may apply more than one time to the same event:
717.6. If a card with an Astrotorium card back would be put into a zone other than the battlefield, exile, or the command zone from anywhere, instead its owner puts it into the command zone. This replacement effect may apply more than once to the same event. This is an exception to rule 614.5.
903.9b If a commander would be put into its owner’s hand or library from anywhere, its owner may put it into the command zone instead. This replacement effect may apply more than once to the same event. This is an exception to rule 614.5.
Before the rule change that caused commander death to be handled as a state-based action rather than a replacement effect, this could clearly change the way in which cards that say "exile it instead of putting it anywhere else" interact with commanders. But that can't happen now that commanders can actually go to exile.
With the current version of the rules, are there any situations in which the rule "This replacement effect may apply more than once to the same event" actually has an impact?