Concentrate your routes on the Main Cities
There are certain cities that appear in a lot of routes, so making sure you get at least two and preferable three of these will help you when you pull more objective cards, since you'll be able to match more routes, and there are a lot of routes to these cities that give big points. Even if you don't ever need to, you should plan your strategy ahead (based on the first cards you pull) to get three of the big four.
Main Cities:
- New York
- Los Angeles
- Seattle
- Miami