This question arises from the modern practice of sometimes bidding say, 1 NT with only a singleton ace (or even king).
I would never do this with a singleton king, but might do with a singleton ace. I'm using a model that says that a singleton ace has about as much "stopper" value as xxx, with a Kx being worth a bit more, and Qx worth just a bit less. I would be reluctant to bid 1NT with xx in my weakest suit, at least unless I had compensation elsewhere in the hand.
I also don't mind bidding 1NT with a 5-4-2-2 shape if the two doubletons are reasonably well guarded, say, Kx and Ax. I would refrain from doing so if the doubletons were weaker, say Kx and xx, or conversely if they were too strong, say AK and AQ, leaving too few values for my longer suits.
Among the expert or near-expert practitioners of such offshape no trump bidding, what guidelines do they use?