While understanding opponent's bidding agreements is pretty important to give advice for this specific hand, the answer to the question you ask in your title is "yes, it can be." Let's look at a few examples.
You hold Axx xxxxx xx xxx
. RHO deals and opponents have the following uncontested auction:
1D
1H 1S
2C 2H
2S 3D
3S 4D
4H 4NT
5C 5S
Under opponents' agreements, RHO has shown something like 4=3=5=1 shape with good diamonds and extras, while LHO has shown 4-4 or 4-5 in the majors with a heart control and extras. LHO has also shown one keycard. Looking at your hand and listening to the auction, partner likely has the club A and a heart singleton or void, and nothing else. To defeat this contract, you'll need a heart ruff. Lead a heart, win the first round of trumps, and continue a heart. Partner will get a ruff and cash the setting trick in the club ace.
Now imagine the same auction, but you hold xx x xxxx Axxxxxx
. Lead a heart hoping that partner holds the hand above.
OK, so those two hands show that one reason to lead dummy's suit is to set up a ruff.
OK, now you hold xxx Kxxx xxxx Kx
. The auction is
LHO Ptnr RHO You
1C P
1S P 2NT P
3NT X all pass
Partner's double asks you to lead dummy's first-bid suit, so lead a spade.
Now you hold xx xxx KQJT9 Axx
. LHO deals and opponents have the following uncontested auction:
1D 1H
1S 1NT
3NT
Lead a diamond. You expect to collect 4 diamonds and the club ace.
Now you hold Ax KQJT QTx J9xx
. The opponents have a Smolen auction:
1NT
2C 2D
3H 3NT
LHO has shown 5 spades and 4 hearts. Lead a heart to attack dummy's entry. With luck, dummy is something like KQJTx Axxx xxx x
. You can hold up the spade ace one round and watch partner's play to figure out which minor you can safely lead away from (perhaps partner has the club Q or ten, or the diamond J or K). Then declarer will be forced to play the minors from their hand, eventually giving you the setting trick.